Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
By A. Facciabene, Xiao-hui Peng, Ian Hagemann, K. Balint, A. Barchetti, Li-ping Wang, P. Gimotty, C. Gilks, P. Lal, Lin Zhang and 1 more. Nature, 2011
1,277 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/95e6f136f15a4efb707d24a54b73ce6c49e3490d
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Rakesh K. Jain
- A. Mantovani
- F. Balkwill
- Richard J. Johnson
- D. Powell
- D. Duda
- George Coukos
- Dai Fukumura
In Oncology
- Rakesh K. Jain
- Triantafyllos Stylianopoulos
- Dai Fukumura
- A. Mantovani
- F. Balkwill
- John D. Martin
- Lance L. Munn
- D. Duda
Citations in the corpus
- Tumor-associated stromal cells as key contributors to the tumor microenvironment (2016, background): “[32] recently reported that Tregs produced VEGF-A, leading to sustained angiogenesis in a mouse model of ovarian cancer.”
- HIF Transcription Factors, Inflammation, and Immunity (2014, background): “CCL28 is another chemokine that is secreted by hypoxic tumor cells and attracts CXCR10 + Treg cells to the tumor site, promoting tumor tolerance and angiogenesis (Facciabene et al., 2011).”
- Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors (2012, background): “Although many immune cells still infiltrate the tumor, hypoxia and acidity—resulting from impaired perfusion—can attenuate their killing potential (53).”
- Cancer-related inflammation: common themes and therapeutic opportunities. (2012, background): “Hypoxia, immune evasion and the formation of new blood vessels are key enabling characteristics of a progressing tumor microenvironment—and recent work [69] shows that, at least in intraperitoneal ovarian cancer, CCL28 might link this ‘vicious triangle’.”
- Vascular normalization as an emerging strategy to enhance cancer immunotherapy (2013, positive): “Third, Treg cells – an immune suppressive lymphoid cell population – may be preferentially recruited into tumors via upregulation of chemotactic factors, such as CCL-22 (10) and CCL-28 induced by tumor hypoxia (14).”
- The role of mechanical forces in tumor growth and therapy (2014, neutral): “But even if these cells arrive in the tumor tissue, hypoxia compromises their killing potential (42).”