A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity
By Dennis H. Kim, Rhonda L. Feinbaum, G. Alloing, Fred E. Emerson, D. Garsin, H. Inoue, Miho Tanaka-Hino, N. Hisamoto, K. Matsumoto, Man-Wah Tan and 1 more. Science, 2002
853 citations recorded by the source corpus.
Subfields: Aging, Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/95bd07ab72cfe3702d871f826ead813b44df8c41
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In Aging
In Molecular Biology
- K. Matsumoto
- Siu Sylvia Lee
- Frederick M. Ausubel
- Dennis H. Kim
- Valerie Reinke
- L. Friedman
- E. Troemel
- S. Chu
Citations in the corpus
- p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, background): “We have previously shown that SEK1 is required for PMK-1 activation, and that the sek-1(ag1) mutation confers enhanced pathogen susceptibility in the glp4(bn2) background as well [5].”
- The host defense of Drosophila melanogaster. (2007, background): “The p38 stress pathway has been implicated in the immune response of plants, Caenorhabditis elegans, and mammals (98, 99).”
- Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial (2006, background): “Our laboratory and others have previously shown that aspects of PA14 pathogenicity are conserved in model hosts and in mammalian hosts; PA14 virulence factors have been shown to be required for disease in both model hosts and mammals [13,14,16,17,19,28,34], and components of the host defense respons”
- ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity (2005, background): “elegans , defense against pathogenic bacteria requires homologs of mammalian apoptosis signal–regulating kinase 1 (ASK1)–p38 signaling component”