Interpretation of Changes in Health-related Quality of Life: The Remarkable Universality of Half a Standard Deviation

By G. Norman, J. Sloan, K. Wyrwich. Medical Care, 2003

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Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. (2010, methodology): “For studies that provided results using continuous data, we estimated an approximate dichotomous equivalent.(12,14) For each question, we usedmeta-analysis forthepooledRRand a 95% confidence interval (CI) for all nontruncatedRCTs.”
Implementing patient-reported outcomes assessment in clinical practice: a review of the options and considerations (2012, background): “, half a standard deviation) [62] or comparison to anchors (e.”
The Tinnitus Functional Index: Development of a New Clinical Measure for Chronic, Intrusive Tinnitus (2012, background): “Minimum Clinically Important Change in TFI Scores • This is an important topic and one that has generated substantial debate among measurement experts (Norman et al. 2003; Terwee et al. 2003).”
Using Anchor-Based Methods to Determine the Smallest Effect Size of Interest (2019, methodology): “difference’ (Norman et al., 2003), but we will use the umbrella term, minimal important difference (King, 2011).”
Minimum clinically important difference in lumbar spine surgery patients: a choice of methods using the Oswestry Disability Index, Medical Outcomes Study questionnaire Short Form 36, and pain scales. (2008, methodology): “5 SD) [17–19] was calculated as half the SD of the baseline scores.”