Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

By M. Riewald, R. Petrovan, A. Donner, B. M. Mueller, W. Ruf. Science, 2002

886 citations recorded by the source corpus.

Subfields: Hematology, Internal Medicine, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/95918829c4c5d88b55493c5d9bfff946ae8791e6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. M. Levi
2. Berislav Zlokovic
3. C. Esmon
4. T. van der Poll
5. V. Ossovskaya
6. N. Bunnett

In Nutrition and Dietetics

1. Berislav Zlokovic

Citations in the corpus

• Novel strategies for the treatment of sepsis (2003, background): “A recent study showed that APC uses the endothelial-cell protein C receptor as a co-receptor for cleavage of protease-activated receptor-1 (PAR-1) on endothelial cell”
• Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis (2007, background): “Its pathophysiological role has been linked to the activated protein C pathway and its induced genes [26,27].”
• Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective (2003, background): “Neither hypoxia nor APC significantly altered the amounts of IAP-1 or the Bcl-2 homolog A1, whereas those two proteins are upregulated by APC in HUVE”
• Protease-activated receptors: contribution to physiology and disease. (2004, background): “These protective actions of APC on endothelial cells are dependent on PAR1 (46, 238).”
• Points of control in inflammation (2002, background): “These include neutralizers of tumour-necrosis factor (TNF); blockers of leukotriene receptors; inhibitors of cyclooxygenase (COX)-2, leukotriene synthetase and 3-hydroxy-3-methylglutaryl coenzyme A reductase; and agonism at protease-activated receptor 1 by activated protein C (ref”
• The interactions between inflammation and coagulation (2005, background): “In u-PAR deficient mice, neutrophil recruitment in a bacterial pneumonia model is markedly reduced (Rijneveld et al, 2002).”
• Extracellular histones are major mediators of death in sepsis (2009, background): “2c ) and not by APC-mediated protease-activated receptor-1 (PAR1) signaling, a known alternative cytoprotective function of AP”
• Inflammation and coagulation (2010, background): “Finally, APC is capable of inhibiting endothelial cell apoptosis, which also seems to be mediated by a mechanism dependent on EPCR–PAR-1 (91, 104).”