Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

By Tong-fei Cheng, Dong Liu, J. Griffin, José A. Fernández, F. Castellino, E. Rosen, K. Fukudome, Berislav Zlokovic. Nature Medicine, 2003

601 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Nephrology

View Paper: https://www.semanticscholar.org/paper/33ee9db091e38b1233be6440b80b7f8f573f7b27

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. M. Levi
2. T. van der Poll
3. V. Ossovskaya
4. N. Bunnett

In Immunology

1. M. Levi
2. T. van der Poll

Citations in the corpus

• Hematologic changes in sepsis and their therapeutic implications. (2004, background): “Failure of clinical trials to demonstrate that either AT or TFPI can improve outcomes in patients with severe sepsis suggests that drotrecogin alfa (activated) not only possesses antithrombotic properties but also modulates endothelial cell function—a property supported by experimental evidence.(67,”
• Protease-activated receptors: contribution to physiology and disease. (2004, background): “These protective actions of APC on endothelial cells are dependent on PAR1 (46, 238).”
• Inflammation and coagulation (2010, background): “Finally, APC is capable of inhibiting endothelial cell apoptosis, which also seems to be mediated by a mechanism dependent on EPCR–PAR-1 (91, 104).”