Diversity, topographic differentiation, and positional memory in human fibroblasts

By Howard Y. Chang, J. Chi, Sandrine Dudoit, Chanda Bondre, M. van de Rijn, David Botstein, Patrick O. Brown. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,173 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/955d00f3dd29e27302ed2670464703dd962bcf49

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Citations in the corpus

Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression (2015, background): “Instead, at least in the case of sarcomas, the corresponding normal cells-of-origin – plausibly cells akin to fibroblasts or mesenchymal stem cells (MSCs), express a variety of EMT-TFs constitutively, ostensibly to maintain their residence in a fully mesenchymal state (Chang et al., 2002).”
The Origin of Fibroblasts and Mechanism of Cardiac Fibrosis (2010, background): “However, this limited view has been challenged by the demonstration of phenotypic heterogeneity among ﬁbroblasts (Chang et al., 2002), not only between organs, but also within the same organ during health and disease (Fries et al., 1994; Jelaska et al., 1999).”
On Having No Head: Cognition throughout Biological Systems (2016, background): “More recent efforts include the notion of memory for position during regeneration (Chang et al., 2002; Kragl et al., 2009; Wang et al., 2009) and development (Beloussov, 1997) and for signaling hysteresis during development (Balaskas et al., 2012), excitable cortex memory models of pseudopod…”
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. (2007, methodology): “Because adult primary fibroblasts are differentiated based on their anatomic site of origin and retain canonical features of the embryonic HOX code (Chang et al., 2002; Rinn et al., 2006), we used HOX tiling arrays to profile polyadenylated transcripts from fibroblasts representing 11 distinct…”
Fibroblasts in fibrosis: novel roles and mediators (2014, background): “In fact, fibroblasts from different skin sites retain positional memory with distinct gene expression profiles (Chang et al., 2002).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “The notion that fibroblasts are a homogeneous cell type irrespective of their specific tissue location has been challenged by studies comparing the gene expression profiles of fibroblasts originating from different organs and showing that patterns of gene expression can highly vary between different”
Wound Healing: A Cellular Perspective. (2019, background): “Differentially expressed genes include those responsible for ECM synthesis, proliferation, and migration, processes that are fundamental for wound healing (54).”
Keratinocyte-fibroblast interactions in wound healing. (2007, background): “Fibroblast diversity was further demonstrated by expression data for fibroblasts derived from different body sites (Chang et al., 2002; Rinn et al., 2006).”