Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population.

By K. Imai, S. Matsuyama, Satoshi Miyake, K. Suga, K. Nakachi. The Lancet, 2000

1,116 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9537035417d39eee19bae8c69f91fd1efe5fa8de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Oncology

Citations in the corpus

Natural killer cells in cancer biology and therapy (2020, background): “In 2000, an 11-year follow-up study of the Japanese general population, with rigorous use of various related biochemical and immunological markers, indicated that elevated cytotoxic activity of peripheral NK cells is positively associated with reduced cancer risk and vice versa, suggesting the certa”
Interleukin-6 in acute exercise and training: what is the biological relevance? (2006, background): “However, others have not observed changes in basal IL-6 levels in response to training (16, 85, 104).”
Functions of natural killer cells (2008, background): “However, an 11-year follow-up epidemiologic survey has shown that the extent of NK cell activity in peripheral blood is associated with cancer risk in adults: low NK cell activity is associated with increased cancer ris”
The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses (2020, background): “NK cells are important in tumor control as a low activity of NK cells has been associated with increment of cancer risk (33).”
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. (2016, positive): “The immune system has a powerful capacity to combat cancer, but chronic inflammation has also been linked to tumorigenesis in several conditions (Vivier et al., 2012; Imai et al., 2000; Grivennikov et al., 2010).”
Cancer despite immunosurveillance: immunoselection and immunosubversion (2006, background): “Moreover, the presence of certain human NKG2D alleles, which affect the natural cytotoxic activity of peripheral-blood lymphocytes, is associated with a risk of developing cancer at any sit”
NK cells and cancer immunosurveillance (2008, background): “In an 11-year follow-up study, it was found that a low NK-like cytotoxicity of peripheral blood lymphocytes correlates with an increased risk for cancer (Imai et al., 2000).”
Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “In humans, an 11-year follow-up study showed that low NK cell cytotoxic activity was correlated to an increased risk of cancer (257) and the presence of tumor-infiltrating NK cells is a positive prognostic marker for multiple malignancies including colorectal carcinoma (258), gastric carcinoma (259)”