Optofluidic Microsystems for Chemical and Biological Analysis

By Xudong Fan, Ian M. White. Nature Photonics, 2011

861 citations recorded by the source corpus.

Optofluidics – the synergistic integration of photonics and microfluidics – has recently emerged as a new analytical field that provides a number of unique characteristics for enhanced sensing performance and simplification of microsystems. In this review, we describe various optofluidic architectures developed in the past five years, emphasize the mechanisms by which optofluidics enhances bio/chemical analysis capabilities, including sensing and the precise control of biological micro/nanoparticles, and envision new research directions to which optofluidics leads.

Subfields: Biomedical Engineering, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/943c5e591adbc2b982225934cf47f8be08ad760c

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Citations in the corpus

Silicon Photonic Biosensors Using Label-Free Detection (2018, methodology): “In addition, optofluidic sensors are extremely suitable for evanescent 518 field RI detection, since the change of RI scales with the analyte bulk concentration or surface density, rather 519 than the number of molecules in total [209].”
Low-Loss Singlemode PECVD Silicon Nitride Photonic Wire Waveguides for 532–900 nm Wavelength Window Fabricated Within a CMOS Pilot Line (2013, background): “In recent years, there has been a tremendous surge of interest towards integration of photonic devices with different functionalities on a chip for biological sensing and detection [1], [2].”
Emerging applications of label-free optical biosensors (2017, methodology): “Recently, two general strategies are used to increase the detection capability of these optical label-free methods: engineering the optical response of the sensing surface [37] and coupling different techniques sensitive to complementary molecular properties [38].”
Highly Sensitive D-Shaped Photonic Crystal Fiber-Based Plasmonic Biosensor in Visible to Near-IR (2017, background): “IN RECENT years, remarkable efforts have been made on photonic crystal fiber (PCF) based surface plasmon resonance (SPR) sensors due to its wide range of applications ranging from medical diagnostics, biochemical, environmental monitoring, and food safety to security [1]–[3].”
Whispering gallery mode sensors (2015, background): “Comparable sensitivities have also been achieved using an integrated sapphire resonator [143]; however, sensitivities of 30, 570, and 700 nm/RIU have been reported in a microsphere resonator [19], a capillary-based optofluidic ring resonator [144,145], and a nanowire loop resonator [146], respective”
The photonic integration of non-solid media using optofluidics (2011, background): “On-chip analysis and sensing is a large field in its own right that is also covered by a Review in this Focus Issu”