Neurosteroids: biosynthesis and function of these novel neuromodulators.
By N. Compagnone, S. Mellon. Frontiers in neuroendocrinology (Print), 2000
810 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/9373c4fc8b25b0ff3ca0b929326463cad1933f4b
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In Cellular and Molecular Neuroscience
In Molecular Biology
In Neurology
Citations in the corpus
- Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA Sulfate (DHEAS) (2008, background): “In the brain, DHEA(S) modulates actions of the c-aminobutyric acid type A (GABAA) receptor, the NMDA receptor, and the sigma subtype 1 (r1) receptor [26,27,32,65,188,193,197] among others [236,266,268].”
- The biology of fear- and anxiety-related behaviors (2002, background): “The neurosteroids are a novel, interesting class of neuromodulators synthesized in the brain directly from cholesterol.(102) They appear to act essentially via an allosteric modulation of the GABAA receptor, although other receptors may also be involved.”
- Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods (2015, background): “The mechanism by which SSRIs increases allopregnanolone levels is thought to involve direct stimulation of 3α-hydroxysteroid dehydrogenase (3α-HSD), an important enzyme in the allopregnanolone biosynthesis (Compagnone and Mellon, 2000).”
- Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. (2004, background): “Evidence for expression of steroidogenic enzymes in brain, spinal cord, and peripheral nervous system include CYP11A, CYP11B1 and B2, CYP17, CYP19, 3 HSD, 17HSD, 5 -reductase and 3 HSD (14, 219, 220).”
- Progesterone receptors: form and function in brain. (2008, positive): “Neurosteroids such as APa are synthesized in the central and peripheral nervous system, primarily by myelinating glial cells, but also by astrocytes and several neuron types [243,193,194,54].”