Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring.

By C. Cooney, A. Dave, G. Wolff. Journal of NutriLife, 2002

802 citations recorded by the source corpus.

Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health, Rheumatology

View Paper: https://www.semanticscholar.org/paper/93556da4dd3772fa0b5dfd824da7239b0483c661

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In Molecular Biology

In Pediatrics, Perinatology and Child Health

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Citations in the corpus

Is folic acid good for everyone? (2008, background): “There were strong correlations between dietary supplementation and the degree of methylation and between methylation and coat color (136, 137).”
Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation (2003, background): “Because A/a coat color correlates with A methylation status (15), it has been inferred that supplementation alters phenotype via A methylation (7).”
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study (2007, background): “Epigenetic regulation, involving DNA methylation, may be another mechanism of nutritional programming, as demonstrated in animal models [43–45].”
Choline: critical role during fetal development and dietary requirements in adults. (2006, positive): “For example, feeding pregnant pseudoagouti Avy/a mouse dams a choline methyl-supplemented diet altered epigenetic regulation of agouti expression in their offspring, as indicated by increased agouti/ black mottling of their coats (28,153).”
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. (2007, background): “In a mice experiment by Cooney et al. (2002), they also showed that diet can have an effect on DNA methylation.”
Early life events and their consequences for later disease: A life history and evolutionary perspective (2007, background): “…changing nutrient balance in the periconceptional period alters for life the methylation status of the mutant gene underlying the agouti phenotype (Cooney et al., 2002; Wolff et al., 1998), again suggesting that the periconceptional period is a stage in which epigenetic change can be induced.”