DNA double-strand break repair: all's well that ends well.

By Claire Wyman, Roland Kanaar. Annual Review of Genetics, 2006

843 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/93299dd3f8eb9acdf14fa260a97c44f6d99b72ae

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Citations in the corpus

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair (2008, background): “In contrast to the NHEJ pathways, homology-directed repair (HDR/GC) and single-strand annealing (SSA) employ significant degrees of homology [15].”
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis (2010, positive): “Efficient HR during S phase may have evolved to repair damage encountered during DNA replicatio”
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. (2011, background): “The homology-directed repair of DSBs is a multistep process requiring the activities of numerous proteins that act in a concerted fashion to re-establish the broken connection (Wyman and Kanaar 2006).”
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice (2013, positive): “…can arise and have allowed design and testing of molecular and genetic strategies for restoring health in diseased animals and humans (e.g. 4–9 In recent years, new methods have been developed that extended targeted gene disruption technologies to human cells in culture, numerous other…”
Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila (2014, background): “HDR repairs DSBs by precisely copying sequence from a donor template, allowing specific changes to be introduced into the genome (2).”
Sources of DNA double-strand breaks and models of recombinational DNA repair. (2014, methodology): “…detailed description of DSB repair in budding yeast has relied on the inducible expression of HO endonuclease or a codon-optimized I-SceI, which can cut cleavage sites introduced in different chromosomal contexts (Krogh and Symington 2004; Haber 2006; Wyman and Kanaar 2006; Kass and Jasin 2010).”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “Different organisms use one of the two major repair pathways predominantly to different extents (Bleuyard et al., 2006; Wyman and Kanaar, 2006; Agmon et al., 2009).”
DNA helicases Sgs1 and BLM promote DNA double-strand break resection. (2008, background): “To survive DSB exposure and maximize genome stability, cells possess a complex machinery to detect DSBs, signal their presence, and mediate their repair (Zhou and Elledge 2000; Rouse and Jackson 2002; Lisby and Rothstein 2004; Wyman and Kanaar 2006).”
Space radiation effects on plant and mammalian cells (2014, background): “Therefore, DSBs are considered to be the most severe because they are more likely to result in chromosome aberrations and genomic instability [35,36] which can ultimately lead to lethal cell damage [37].”
Repair of strand breaks by homologous recombination. (2013, background): “In mammalian cells, like in yeast, recombination proteins are recruited to DSBs and many of these steps are conserved (Wyman and Kanaar 2006).”