A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans

By Limin Liu, A. Hausladen, M. Zeng, L. Que, J. Heitman, J. Stamler. Nature, 2001

888 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/921f1311d7d5474e1acc1ea4a51a96fc41147fe7

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In Immunology

1. D. Auld
2. B. Kalyanaraman
3. H. Forman
4. S. Rhee
5. J. Hancock
6. Radhika Desikan
7. V. Lushchak
8. S. Neill

In Molecular Biology

1. S. Neill
2. J. Hancock
3. Radhika Desikan
4. B. Kalyanaraman
5. H. Forman
6. D. Auld
7. S. Rhee
8. V. Lushchak

In Physiology

1. D. Auld
2. H. Forman
3. S. Rhee
4. J. Hancock
5. Radhika Desikan
6. V. Lushchak
7. S. Neill
8. Toren Finkel

Citations in the corpus

• Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “Under normal conditions, when a cell is not stressed, the processes that generate ROS are well counterbalanced by antioxidant systems.”
• Protein S-nitrosylation: purview and parameters (2005, background): “GSNO is thought to be the main non-protein SNO in cells and in extracellular fluids38, and Liu et al.39 discovered that the glutathione-dependent formaldehyde dehydrogenase functions across phylogeny and cell type as a specific GSNO reductase (GSNOR) to metabolize Figure 1 | Cellular sources and tar”
• Hydrogen peroxide and nitric oxide as signalling molecules in plants. (2002, background): “Mutant yeast which lacked this gene showed enhanced susceptibility to nitrosative challenge, indicating an important biological role for this enzyme (Liu et al., 2001).”
• Nitric oxide as a bioactive signalling molecule in plant stress responses (2007, background): “The Arabidopsis GS-FDH exhibits a strong GSNO reductase (GSNOR) activity, which has been demonstrated also for the enzyme from different organisms [140,141].”
• Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity (2004, background): “If the interaction with DNA occurs at the trinucleotide 5 -NGC-3 , then the drug intercalates between N and G and covalently bonds to the G-base on one strand using HCHO, and to the G-base on the opposing strand using hydrogen bonds.”
• Redox-based regulation of signal transduction: principles, pitfalls, and promises. (2008, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript consisting of cysteine/cystine, GSH/GSSG, and Trx-SH/Trx-SS to control the redox tone [114], a concept that also warrants inclusion of measurements of NO/SNO homeostasis (nitroso-redox homeostasis).”
• Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “In addition, although Hb represents an important mechanism through which NO levels could be modulated, the formation of low molecular weight nitroso conjugates with glutathione is thought to be the first step in a glutathione-linked NO removal pathway (Liu et al., 2001).”
• Zinc coordination sphere in biochemical zinc sites (2001, methodology): “macrophages and identified as class III (χ) ADH (Liu et al. 2001).”
• Nitric oxide signalling in plants. (2003, background): “Stamler’s group recently characterised an enzyme activity from Escherichia coli that degrades GSNO (Liu et al., 2001).”