Antibiotics in early life alter the murine colonic microbiome and adiposity

By Ilseung Cho, S. Yamanishi, Laura M. Cox, B. Methé, Jiri Zavadil, Kelvin Li, Zhan Gao, D. Mahana, K. Raju, Isabel Teitler and 3 more. Nature, 2012

1,517 citations recorded by the source corpus.

Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic antibiotic therapy to young mice and evaluated changes in the composition and capabilities of the gut microbiome. Administration of subtherapeutic antibiotic therapy increased adiposity in young mice and increased hormone levels related to metabolism. We observed substantial taxonomic changes in the microbiome, changes in copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids, increases in colonic short-chain fatty acid levels, and alterations in the regulation of hepatic metabolism of lipids and cholesterol. In this model, we demonstrate the alteration of early-life murine metabolic homeostasis through antibiotic manipulation.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/91f2faa1dd0488419fdcf8d0882e1f8e33a19779

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Citations in the corpus

Antibiotic use and its consequences for the normal microbiome (2016, background): “, biodiversity loss), leads to metabolic perturbations that affect adiposity and bone growth and alter normal immunologic development (6, 7).”
Antimicrobial resistance in humans, livestock and the wider environment (2015, positive): “The mechanism underlying growth promotion remains uncertain [13]; it works for antibacterials but not antifungals or antivirals, and it works for a variety of animal species including human children [14].”
The Intestinal Microbiome in Early Life: Health and Disease (2014, background): “showed these sub-therapeutic doses are sufficient to alter the intestinal microbiota, which resulted in enrichment of key microbial genes involved in carbohydrate metabolism to create SCFAs, as well as systemic changes to hepatic lipid and cholesterol metabolism, leading to increased adiposity in yo”
Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health (2020, background): “Furthermore, such imbalances in the gut flora can dysregulate developme t of the immune system, which may affect adiposity a d bone gr wth; this is p r cularly unfavorable in the e rly years of life [31,32].”
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences (2014, methodology): “Although our results confirm the previously observed latelife hepatic effects (Cho et al., 2012), such as altered expression of genes involved in fatty acid metabolism (e.”
Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016, background): “The microbiota is a dynamic ecosystem which is influenced by several factors including genetics, diet, metabolism, age, geography, antibiotic treatment, and stress (Hufeldt et al., 2010; Cho et al., 2012; Drago et al., 2012).”
Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review (2017, background): “the composition of gut microbiota, but also their metabolic capability by selecting for microbial species that were capable of extracting a high proportion of calories from complex carbohydrates (increase in copies of genes involved in metabolism of carbohydrates to short-chain fatty acids (SCFA)) (”
Disentangling Interactions in the Microbiome: A Network Perspective (2016, background): “Capturing Microbiome Dynamics Under steady conditions, microbial communities can remain stable for long periods of time [38], but they can also change abruptly in response to small perturbations, such as antibiotic treatment [39] or change in diet [40].”
The Dynamics of the Human Infant Gut Microbiome in Development and in Progression towards Type 1 Diabetes (2015, positive): “…microbiome development may have a role in promoting susceptibility to or protection from disease later in life; this has been demonstrated in mice (Cho et al., 2012; Cox et al., 2014), and it may also be true for type 1 diabetes (T1D) (Brown et al., 2011; Giongo et al., 2011; de Goffau et al.,…”