Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex
By W. Lee, Hayden Huang, G. Feng, J. Sanes, Emery N. Brown, P. So, E. Nedivi. 2005
270 citations recorded by the source corpus.
Despite decades of evidence for functional plasticity in the adult brain, the role of structural plasticity in its manifestation remains unclear. To examine the extent of neuronal remodeling that occurs in the brain on a day-to-day basis, we used a multiphoton-based microscopy system for chronic in vivo imaging and reconstruction of entire neurons in the superficial layers of the rodent cerebral cortex. Here we show the first unambiguous evidence (to our knowledge) of dendrite growth and remodeling in adult neurons. Over a period of months, neurons could be seen extending and retracting existing branches, and in rare cases adding new branch tips. Neurons exhibiting dynamic arbor rearrangements were GABA-positive non-pyramidal interneurons, while pyramidal cells remained stable. These results are consistent with the idea that dendritic structural remodeling is a substrate for adult plasticity and they suggest that circuit rearrangement in the adult cortex is restricted by cell type–specific rules.
Subfields: Representation & Self-Supervised Learning, Neuroscience
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Citations in the corpus
- The frontier of simulation-based inference (2019, background): “The Journal of Chemical Physics 21(6):1087–1092.”
- Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex. (2006, unknown): “Using conservative criteria, 25% of A1 and 60% of A2 axon branches, as well as all most distal axonal endings, grew and retracted over distances of up to w150 mm. This plasticity exceeds the largest changes seen in dendritic branches of pyramidal neurons (Trachtenberg et al., 2002; Mizrahi and Katz,”
- Anatomical and physiological plasticity of dendritic spines. (2007, background): “Branches of pyramidal neurons in cortical layers 5 and 2/3 (Trachtenberg et al. 2002, Lee et al. 2006) and mitral and tufted cells in the olfactory bulb (Mizrahi & Katz 2003) of adult rats show no branch addition or retraction over weeks and months.”
- Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy (2011, result): “This hypothesis is contrary to results from neocortical pyramidal cell”
- Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window (2009, unknown): “, some cell-types display large-scale changes at the level of dendriti”