Whole-cell simulation: a grand challenge of the 21st century.

By Masaru Tomita. Trends in Biotechnology, 2001

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Modeling and Simulation of Genetic Regulatory Systems: A Literature Review (2002, positive): “…have been launched in recent years, including the simulation of a virtual cell using the E-CELL or initial cell environments (Tomita et al ., 1999; Tomita, 2001; Loew and Schaff, 2001), the simulation of the development of the Drosophila embryo in the framework of the Virtual Drosophila project…”
Evolutionary programming as a platform for in silico metabolic engineering (2005, background): “Although there have been some attempts to simulate dynamic behavior of whole cell systems [8,9], currently these approaches enjoy limited applicability due to lack of kinetic and regulatory information on the whole genome scale.”