Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus

By A. Bakker, C. Kirwan, Michael Miller, Craig E. L. Stark. 2008

1,099 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, positive): “Recent experimental evidence also supports the pattern separation function of the dentate gyrus in information processin”
Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis (2011, methodology): “Based on the position of the DG as the major local input to the CA3, this separation function appeared consistent with the role of the hippocampus in memory formation (Rolls, 1996; Kesner, 2007; McHugh et al. , 2007; Bakker et al. , 2008).”
Automated Volumetry and Regional Thickness Analysis of Hippocampal Subfields and Medial Temporal Cortical Structures in Mild Cognitive Impairment (2014, methodology): “These include template-based approaches [Apostolova et al., 2006; Bakker et al., 2008; Yushkevich et al., 2009; Wang et al., 2006], which segment the hippocampus as a single structure, deform the segmented hippocampi to a volumetric or surface template, and associate regional statistics (e.g.,…”
Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory. (2015, neutral): “It has been thought that the DG-CA3 circuit generates context-specific information and contributes to the discrimination of contexts, spaces, and events (Bakker et al., 2008; Leutgeb et al., 2007; Marr, 1971; O'Reilly and McClelland, 1994; Treves and Rolls, 1994).”
Computational influence of adult neurogenesis on memory encoding. (2009, positive): “…which has been predicted theoretically (McNaughton and Morris, 1987; O'Reilly and McClelland, 1994; Treves and Rolls, 1992) and examined using behavioral and physiological approaches (Bakker et al., 2008; Jung and McNaughton, 1993; Kesner et al., 2004; Leutgeb et al., 2007; McHugh et al., 2007).”
CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation (2014, background): “Other studies that investigated both input and output patterns worked under experimental conditions in which CA3 reflected pattern separation, precluding a test of its hypothesized pattern completion functions (Bakker et al., 2008; Leutgeb et al., 2007).”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, neutral): “A different pattern of activity was seen in DG/CA3 upon presentation of a repeated image, but not in CA1 or EC, indicating that the latter areas do not have the same sensitivity to small differences (Bakker et al., 2008).”
Strong Evidence for Pattern Separation in Human Dentate Gyrus (2016, methodology): “In contrast, previous fMRI studies of the MTL that investigated pattern separation relied on 3 T fMRI and isotropic voxel sizes up to 1.5 mm (corresponding to a volume of 3.375 mm 3; Bakker et al., 2008; Carr et al., 2010).”
The molecular and systems biology of memory. (2014, positive): “High-resolution imaging of the hippocampus revealed differences between hippocampal subfields, with activity consistent with pattern separation in the CA3/dentate gyrus region and activity consistent with pattern completion in CA1 and subiculum (Bakker et al., 2008).”
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation (2011, background): “Functional MRI showed that the presentation of objects that were highly similar, but not identical, to previously seen objects elicited increased blood flow in the human DG/CA3 region (Bakker et al., 2008).”
Decoding the tradeoff between encoding and retrieval to predict memory for overlapping events (2018, neutral): “We used an automatic artifact correction algorithm based on (Nolan et al., 2010) using Independent Components Analysis (ICA; Bell and Sejnowski, 1995; Onton and Makeig, 2006) to detect and correct for eye blinks and saccades.”
The Episodic Memory System: Neurocircuitry and Disorders (2009, neutral): “Similarly to rodent studies, initial experiments suggest that CA3 or dentate gyrus has an important function in pattern separation within the hippocampal formation (Bakker et al, 2008).”
The hippocampus and inferential reasoning: building memories to navigate future decisions (2012, background): “Future animal research or human neuroimaging studies utilizing high-resolution fMRI techniques (Zeineh et al., 2003; Bakker et al., 2008; Preston et al., 2010) may provide additional insight into the precise hippocampal mechanisms that support the type of mnemonic flexibility required in…”