Structural and functional conservation at the boundaries of the chicken β‐globin domain

By N. Saitoh, A. Bell, F. Recillas-Targa, A. West, M. Simpson, M. Pikaart, G. Felsenfeld. 2000

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Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci (2002, methodology): “These binding affinities were somewhat stronger than that seen with the chicken 3HS-A site, which was shown previously to be a weaker binding element than the chicken FII site ( 36 ) (Table 1). These differences in binding strength indicate that while the central conserved sequences of these sites a”
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. (2007, unknown): “A similar CTCF-dependent insulator site was subsequently found at the 3 (cid:1) end of the locus and both sites coincide with erythroid-specific transitions in DNase I sensitivity of chromatin (Saitoh et al. 2000).”
CTCF: Master Weaver of the Genome (2009, unknown): “Another CTCFdependent insulator sequence was subsequently identified by the same group at the 3′ end of this domain (Saitoh et al., 2000) in parallel with the discovery of four CTCF-binding sites within the imprinted control region (ICR) of the mammalian H19/Igf2 locus (Bell and Felsenfeld, 2000; Ha”