Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

By Sébastien Bouret, Shin J. Draper, R. Simerly. Science, 2004

1,210 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/909a9e25a01a03dac16134db49d71f465e71dfce

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Citations in the corpus

Child health, developmental plasticity, and epigenetic programming. (2011, background): “Whereas it is generally held that the mouse is neurologically immature at birth, relative to the human, it is possible that the timing of specific developmental mechanisms is conserved from mouse to human (556).”
Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications (2010, background): “In addition to immediate effects, long-term leptin administration may result in the rewiring of the connections among hypothalamic neurons (that is, it promotes synaptic plasticity) (25, 26).”
Neonatal leptin treatment reverses developmental programming. (2005, background): “ticity of the hypothalamus (27), and the pancreas in the”
Early life events and their consequences for later disease: A life history and evolutionary perspective (2007, background): “At a mechanistic level this may involve the synaptogenic actions of leptin (Bouret et al., 2004) or its peripheral actions, for example on pancreatic cell apoptosis and proliferation (Islam et al., 2000; Shimabukuro et al., 1998).”
Genetics of obesity in humans. (2006, background): “In mice, hypothalamic neurones projecting from the arcuate nucleus to the paraventricular nucleus develop after birth, and their development is regulated by leptin (59).”
The Hormonal Control of Food Intake (2007, positive): “Leptin appears also to be a neurotrophic growth factor during hypothalamic development (Bouret et al., 2004) with leptin deficiency severely reducing the density of innervations from the arcuate nucleus to the paraventricular nucleus, lateral hypothalamus, and dorsomedial nucleus—all regions implica”
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “Neural projections from the ARC to the paraventricular nucleus are reduced in ob/ob mice, and these deficits are restored by leptin treatment during early life [46].”
Ten Putative Contributors to the Obesity Epidemic (2009, positive): “There is evidence that leptin has effects on hypothalamic maturation (Bouret et al., 2004) and a key research question is whether this effect has a critical period which is accessible in other species, such as the human, more mature at birth.”