THE MSC: AN INJURY DRUGSTORE
By A. Caplan, D. Correa. Cell Stem Cell, 2011
1,612 citations recorded by the source corpus.
Summary Now that Mesenchymal Stem Cells (MSCs) have been shown to be perivascular in vivo, the existing traditional view that focuses on the multipotent differentiation capacity of these cells should be expanded to include their equally interesting role as cellular modulators that brings them into a broader therapeutic scenario. We discuss existing evidence that leads us to propose that during local injury, MSCs are released from their perivascular location, become activated and establish a regenerative microenvironment by secreting bioactive molecules and regulating the local immune response. These trophic and immunomodulatory activities suggest that MSCs may serve as site-regulated “drugstores” in vivo.
Subfields: Genetics, Pulmonary and Respiratory Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/9076d64afd0ce2af919d39f01631c1c8678c6243
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In Genetics
Citations in the corpus
- Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration (2012, background): “The identity and in vivo multipotency of putative MSCs from various different tissues has been a source of controversy (Caplan and Correa, 2011).”
- Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis (2014, critical): “This might contradict the hypothesis that MSCs act beneficially as ‘‘medicinal MSCs’’ that become activated and promote tissue regeneration after injury (Caplan and Correa, 2011) or the fact that exogenous infused MSCs promote regeneration or ameliorate progression in many diseases.”
- Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, neutral): “Although the prevailing view is that MSCs help tissue repair without directly contributing to it (reviewed in [32,33]), the results showing that these cells (both human and nonhuman) have the ability to differentiate into distinctive specialized cells in vivo [47,50,98–103] cannot be completely…”