Antibiotic resistance and its cost: is it possible to reverse resistance?
By D. Andersson, D. Hughes. Nature Reviews Microbiology, 2010
2,246 citations recorded by the source corpus.
Subfields: Applied Microbiology and Biotechnology, Genetics, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/904e7d12b3741abab0358c055488d9235dc20899
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Citations in the corpus
- The fitness costs of antibiotic resistance mutations (2014, background): “Three hypotheses could account for the persistence of AMR strains in the absence of antibiotic (Box 1; Andersson 2003; Andersson and Hughes 2010).”
- Mechanisms and consequences of bacterial resistance to antimicrobial peptides. (2016, background): “A number of experimental and clinical studies have hown that the fitness cost of antibiotic resistance can be efficiently nd rapidly reduced by compensatory mutations and that compenated mutants can rapidly sweep a resistant population of bacteria Andersson and Hughes, 2010).”
- Management Options for Reducing the Release of Antibiotics and Antibiotic Resistance Genes to the Environment (2013, background): “…anti biotic resistance may decline after relaxation of selection pressures, low yet detectable levels of resistance determinants are likely to persist for decades because of the low fitness costs associated with many antibiotic resistance mechanisms (Andersson and Hughes 2010; Johnsen et al. 2011).”
- Silver Nanoparticles as Potential Antibacterial Agents (2015, background): “Antimicrobial resistance is a complex mechanism whose etiology depends on the individual, the bacterial strains and resistance mechanisms that are developed [6].”
- Antimicrobial peptides: key components of the innate immune system (2012, background): “Studies on fitness and dynamics of resistance development in various pathogens have led to the conclusion that antibiotic resistance does not occur in some cases, or occurs only at a very slow rate, as this is too costly in term of fitness (Andersson and Hughes, 2010).”
- Antibiotics and the gut microbiota. (2014, neutral): “Once present in the community, selective pressures and opportunities to mitigate the costs of antibiotic resistance (35) likely contribute to its maintenance by the ecosystem.”
- Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistance (2013, background): “(Andersson and Hughes 2010, 2011; Cottell et al. 2012).”
- Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant. (2012, background): “The prevalence and persistence of antibiotic resistance in bacterial pathogens have become an emerging threat to public health, which is raising considerable concern (Andersson and Hughes, 2010).”
- Antibiotic resistome in the livestock and aquaculture industries: Status and solutions (2020, background): “This is because that the susceptible bacteria could be able to outcompete the resistant bacteria if the selective pressure from antibiotics is reduced (Andersson & Hughes, 2010).”
- Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “A recently published review by Andersson and Hughes (278) highlights some of the main examples of chromosomal compensation of fitness costs.”
- Predicting evolution (2017, background): “For example, resistance or antigenic mutations often have deleterious effects on the folding stability or other conserved functions of a protein 54,57–61 A crucial and largely unexplored determinant of predictability is the variation in initial conditions and environmental factors across . a ,…”