Silver Nanoparticles as Potential Antibacterial Agents
By G. Franci, A. Falanga, S. Galdiero, Luciana Palomba, M. Rai, G. Morelli, M. Galdiero. Molecules, 2015
1,490 citations recorded by the source corpus.
Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advances in nanotechnology have opened new horizons in nanomedicine, allowing the synthesis of nanoparticles that can be assembled into complex architectures. Novel studies and technologies are devoted to understanding the mechanisms of disease for the design of new drugs, but unfortunately infectious diseases continue to be a major health burden worldwide. Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. Currently nanotechnology and nanomaterials are fully integrated in common applications and objects that we use every day. In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. This review aims to summarize the emerging efforts to address current challenges and solutions in the treatment of infectious diseases, particularly the use of nanosilver antimicrobials.
Subfields: Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/830cd73da19f5b55dd6a807b02c648cdb8c8b622
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Citations in the corpus
- A Review of Silver Nanoparticles: Synthesis Methods, Properties and Applications (2015, background): “Among various metals, silver nanoparticles (AgNPs) are of particular interest due to their remarkable antimicrobial and localized surface plasmon resonance properties, which render them unique properties such as broad-spectrum antimicrobial [1-3], surface-enhanced Raman spectroscopy (SERS) [4,5], ch”
- Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview (2018, background): “The possible toxicity mechanisms related to AgNPs are depicted in Figure 2 [241].”
- Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies (2018, methodology): “is one of the major disulfide reductase systems used by bacteria against oxidative stress.49 It was demonstrated that Ag+ binds to the active sites of Staphylococcus aureus TrxR and Trx and leads to oligomerization and functional disruption of TrxR as well as Trx. Ag+ also depleted intracellular thi”