Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

By Joanna L. Jankowsky, Daniel J. Fadale, Jeffrey Anderson, Guilian Xu, V. Gonzales, Nancy A. Jenkins, N. Copeland, Michael K. Lee, L. Younkin, S. Wagner and 2 more. 2004

1,418 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/8faa2f92e09043234a231a254ca8fc9528026805

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Marcus E. Raichle
2. E. K. Kim
3. E. Choi
4. Ygor P. Silva
5. D. Holtzman
6. A. Bernardi
7. R. Frozza

In Pharmacology

1. E. K. Kim
2. E. Choi
3. D. Holtzman

In Physiology

1. D. Holtzman
2. Marcus E. Raichle
3. E. K. Kim
4. E. Choi
5. John R. Cirrito
6. Berislav Zlokovic
7. J. Long

Citations in the corpus

• Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy (2009, methodology): “Similarly, the combination of PS1dE9 with APPswe mutation strongly shifts the gamma-cleavage of A toward A 1– 42 (Jankowsky et al., 2004; Minkeviciene et al., 2008).”
• The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “Given that AD has a complex pathology and that therapies that effectively halt the disease progression are still lacking, recent studies have focused on environmental components and diet-based possible prevention strategies by using transgenic animal models (161, 162).”
• Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice (2008, background): “This process is observed at the age of 8 months and appears to precede or parallel the increase in A levels observed in PS1-APP mice at that age (Jankowsky et al., 2001, 2004).”
• Identification of Amyloid Plaques in Retinas from Alzheimer’s Patients and Noninvasive In Vivo Optical Imaging of Retinal Plaques in a Mouse Model (2010, neutral): “Mice used in this study were genotyped for the presence of the transgenes by PCR, as previously described (Jankowsky et al., 2004b).”
• Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “the three genes encoding amyloid precursor protein (APP) [17], presenilin-1 [18], or presenilin-2 [19], whereas most cases of sporadic AD are thought to result from multiple gene defects [20].”
• Neuronal activity regulates the regional vulnerability to amyloid-β deposition (2011, methodology): “To test this hypothesis, we used 7-month-old APPswe; PSEN1ΔE9 (APP/PS1”