The molecular architecture of the nuclear pore complex

By F. Alber, S. Dokudovskaya, L. Veenhoff, Wenzhu Zhang, Julia Kipper, Damien P. Devos, Adisetyantari Suprapto, O. Karni-Schmidt, Rosemary Williams, Brian T. Chait and 2 more. Nature, 2007

1,090 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8f990a0781dcfeeb1e04e69035e8e2bd70c9f239

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Citations in the corpus

Integrative structure modeling with the Integrative Modeling Platform (2017, methodology): “For example, in the case of characterizing the molecular architecture of the NPC, 17,18 atomic structures of the protein subunits were not available, but the approximate size and shape of each protein was known, so each protein was represented as a “string” of connected spheres whose volumes were…”
Outcome of a Workshop on Applications of Protein Models in Biomedical Research (2009, methodology): “The resulting low-resolution map was combined with atomic structures and homology models of constituent proteins, resulting in insights about the evolution and function of the NPC.”
The beginning of a beautiful friendship: cross-linking/mass spectrometry and modelling of proteins and multi-protein complexes (2010, methodology): “In even larger assemblies, cross-linking may substitute for protein co-purification data such as used in reconstructing the nuclear pore complex (Alber et al., 2007a,b).”
Protein–protein interaction and quaternary structure (2008, background): “Thus, a structural model of the nuclear pore (Alber et al. 2007) could be built by assigning a fold type to domains in the constituent proteins, modelling the domains and assembling them by optimizing a score function under a large number of restraints derived from experiment.”
Integrative Structure and Functional Anatomy of a Nuclear Pore Complex (2018, methodology): “1; Supplementary Table 3; Supplementary Videos 1–3): (1) gathering data, (2) representing subunits and translating data into spatial restraints, (3) configurational”
The nuclear pore complex: bridging nuclear transport and gene regulation (2010, methodology): “A detailed architectural map of the yeast NPC was recently determined using a computational approach that combined proteomic, biophysical and imaging dat”
The Protein Structure Initiative: achievements and visions for the future (2012, background): “Structural Genomics platforms are providing extensive structural coverage of proteins from a specific organisms, such as Thermatoga maritima [43] and Mycobacterium tuberculosis [44], or proteins from organelles, such as mitochondria [45] or nuclear pore complexes [46].”
Arbuscular mycorrhiza: the mother of plant root endosymbioses (2008, background): “In humans and yeast, both of these proteins belong to the same NUP107–160 subcomplex of the nuclear pore and are not in contact with substrates of the canonical import and export pathway”
Prediction of Protein Binding Regions in Disordered Proteins (2009, background): “MAP2 projection domain [10], titin’s PEVK domain [11], NF-M and NF-H between neurofilaments [12,13], nucleoporin complex [14]).”
Putting the Pieces Together: Integrative Modeling Platform Software for Structure Determination of Macromolecular Assemblies (2012, methodology): “IMP has been used to produce a number of models; for example, a eukary- otic ribosome [26], a mammalian ribo- some [27], a ryanodine receptor channel [28], the 26S proteasome [1], the Hsp90 chaperonin [29], the TRiC/CCT chaper- onin [30], the actin-scruin complex [31], chromatin [3], and the NPC [4]”