The Protein Structure Initiative: achievements and visions for the future

By Gaetano T. Montelione. 2012

52 citations recorded by the source corpus.

The Protein Structure Initiative (PSI) was established in 2000 by the National Institutes of General Medical Sciences with the long-term goal of providing 3D (three-dimensional) structural information for most proteins in nature. As advances in genomic sequencing, bioinformatics, homology modelling, and methods for rapid determination of 3D structures of proteins by X-ray crystallography and nuclear magnetic resonance (NMR) converged, it was proposed that our understanding of the biology of protein structure and evolution could be greatly enabled by ‘genomic-scale’ protein structure determination. Over the past 12 years, the PSI has evolved from a testing bed for new methods of sample and structure production to a core component of a wide range of biology programs.

Subfields: Materials Chemistry, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. András Szilágyi
2. Yang Zhang
3. Jianyi Yang
4. Robin Pearce
5. Dong Xu
6. Sitao Wu
7. Chengxin Zhang
8. Ambrish Roy

In Molecular Biology

1. András Szilágyi
2. Yang Zhang
3. Jianyi Yang
4. Robin Pearce
5. Ambrish Roy
6. Sitao Wu
7. Dong Xu
8. Chengxin Zhang

Citations in the corpus

• Template-based structure modeling of protein-protein interactions (2013, background): “Despite signifi cant efforts in traditional structural biology and the structural genomics projects that aim at hi gh-throughput complex structure determination [4], the latest statistics show that only ~6% of the known protein interactions in the human interactome have an associated experiment al c”