A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors

By S. Maerkl, Stephen R. Quake. Science, 2007

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Predicting evolution (2017, background): “For example, specific interactions between antigens and immune receptors can be inferred by deep mutational scans 99,100 , similar scans map regulatory DNA–protein interactions 98,101–103 .”
How a protein searches for its site on DNA: the mechanism of facilitated diffusion (2009, background): “Such a landscape picture is also consistent with recent microfluidic measurements of the binding energy for the yeast Cbf1 protein to all possible short DNA sequences [44].”
Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence (2011, background): “and mechanically induced trapping of molecular interactions (MITOMI”
Frequency-specific flow control in microfluidic circuits with passive elastomeric features (2009, background): “Although strategies based on externally actuated valves have enabled marked breakthroughs in chip-based analysi”
Universally Sloppy Parameter Sensitivities in Systems Biology Models (2007, background): “[8] Maerkl SJ, Quake SR (2007) A systems approach to measuring the binding energy landscapes of transcription factors.”