Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.

By P. Kern, S. Ranganathan, Chunling Li, Linda Wood, G. Ranganathan. American Journal of Physiology. Endocrinology and Metabolism, 2001

1,971 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/8e8c88033aaf78f8e83b68f8f3042865e9cda3c3

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In Cardiology and Cardiovascular Medicine

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Citations in the corpus

Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “As with IL-6, TNFα levels positively correlate with adiposity, BMI, insulin levels, and insulin resistance (267, 268).”
Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6 (2005, background): “Adipocytes secrete IL-6 [16,29], one of the chief inducers of CRP production by the liver [30,31].”
Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. (2004, background): “TNF by adipose tissue (27, 28) as well as elevated levels of”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “Of relevance in this regard is that BMI has been shown to correlate with increased peripheral markers of inflammation, in part related to the capacity of adipose tissue to produce IL-6 and other cytokines (114,115).”
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies (2015, background): “Circulating IL-6 levels are elevated in obese and insulinresistant subjects.(273,274) It can be speculated that a persistent increase in levels of IL-6, such as those that occur in a state of inflammation such as obesity and type 2 diabetes, may trigger insulin resistance.”
Molecular and cellular endocrinology (2000, neutral): “Because IL-6 also has effects on glucose transport and insulin action (Kern et al., 2001), the reduction of hepatic IL-6 expression levels by yerba maté could help restore these parameters in our model.”
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “…strongly supported by many findings and clinical evidence; for instance, inflammatory markers such as CRP, TNF-α, and interleukin 6 (IL-6) are elevated in obese and insulin-resistant subjects (Dandona et al., 1998; Kern et al., 2001; Vozarova et al., 2001; Phosat et al., 2017; Uemura et al., 2017).”