Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid

By P. Tangvoranuntakul, P. Gagneux, Sandra Díaz, M. Bardor, N. Varki, A. Varki, E. Muchmore. Proceedings of the National Academy of Sciences of the United States of America, 2003

628 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/8e66a5b5fe5c2a2fd1d2684463232695b1c0a783

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Fred H. Gage
2. L. Bode
3. A. Varki

In Molecular Biology

1. A. Varki
2. L. Bode
3. Fred H. Gage
4. Alysson Renato Muotri
5. Hongjun Song
6. R. Schauer

In Surgery

1. Fred H. Gage
2. A. Varki

Citations in the corpus

• Human embryonic stem cells express an immunogenic nonhuman sialic acid (2005, methodology): “But they can potentially take Neu5Gc up from media containing animal products, activate it into CMP-Neu5Gc, and metabolically incorporate it using the same Golgi transporter and sialyltransferases as CMP-Neu5A”
• Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins (2015, background): “Of two reports of 4-O-Ac Sias in humans, one involved a Sia variant, Neu4Ac5Gc (Miyoshi et al., 1986), of established non-human, dietary origin (Banda et al., 2012; Tangvoranuntakul et al., 2003).”
• Sialic acids in human health and disease (2008, positive): “Such circulating antibodies could also be of pathological relevance, as normal humans are meanwhile consuming Neu5Gc in food and metabolically incorporating it into cell types such as endothelia and epithelia [34].”
• Human milk oligosaccharides: every baby needs a sugar mama. (2012, background): “It remains to be investigated whether incorporation of infant formula-derived exogenous Neu5Gc into rapidly growing neonatal tissues affect infant health (Irie and Suzuki 1998; Tangvoranuntakul et al. 2003; Taylor et al. 2010).”