Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation

By Shobha Vasudevan, Yingchun Tong, J. Steitz. Science, 2007

2,936 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e2289e789dea25cf51fcecbe677d5fa4f7107db

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. John S. Mattick
2. Marcel E. Dinger
3. George A. Calin
4. Tim R. Mercer
5. M. Ferracin
6. Ryan J. Taft
7. Ken C. Pang
8. Olivier Voinnet

In Genetics

1. John S. Mattick
2. C. Harris
3. A. Robles
4. John J. Rossi
5. Olivier Voinnet
6. George A. Calin
7. Nahum Sonenberg
8. W. Filipowicz

In Molecular Biology

1. John S. Mattick
2. Marcel E. Dinger
3. Tim R. Mercer
4. George A. Calin
5. Ryan J. Taft
6. Nahum Sonenberg
7. Ken C. Pang
8. Olivier Voinnet

Citations in the corpus

• MicroRNAs in development and disease. (2011, background): “Remarkably, miRNAs have also been observed to enhance translation in quiescent cells (631).”
• Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. (2009, background): “Activation by miRNAs During the last years, several groups have reported that miRNAs can activate rather than repress their targets under certain conditions [5 ,6 ,7 ,8,48 ,49].”
• The role of let-7 in cell differentiation and cancer. (2010, background): “While in proliferating cells it inhibits translation, in cells arrested in the cell cycle let-7 can actually induce translation (Vasudevan et al. 2007).”
• CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs (2016, background): “In some cases miRNAs may enhance mRNA translation.(24,25) MicroRNAs are initially synthesized as primary”
• Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “These reports indicate that posttranscriptional upregulation by microRNAs is selective, specific to the RNA sequence context, and associated with miRNP factors and other RNA binding proteins [86].”
• Deciphering miRNAs’ Action through miRNA Editing (2019, background): “However, the biology of miRNAs is much more complex than initially thought [1,2].”
• The mammalian ovary from genesis to revelation. (2009, background): “In a complex twist to the miRNA dogma, recent evidence indicates that miRNAs may also activate translation under rare conditions (610).”