Tau pathology and neurodegeneration.

By M. Spillantini, M. Goedert. Lancet Neurology, 2013

1,034 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8e106798cc051d5859278249a870fdea5a554b26

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Citations in the corpus

Neuronal Cell Death. (2018, neutral): “, frontotemporal dementia with Parkinsonism linked to c17 (FTDP-17T), corticobasal degeneration (CBD), Pick’s disease (643)], and together with AD, this group of diseases is termed “tauopathies”.”
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “Pathological studies have shown the deposition of abnormal proteins in the brain tissues of FTD patients, including TDP-43 (50% of cases), tau (40% of cases), and FUS (5–10% of cases).(314,315) Gene mutation is an important pathogenic factor for FTD.”
Pathology of Neurodegenerative Diseases. (2017, background): “Disorders associated with pathological accumulation of tau protein in neurons and glia are referred to as tauopathies (Lee et al. 2001; Dickson et al. 2011; Spillantini and Goedert 2013; Kovacs 2015) and further subdivided as either primary or secondary.”
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade. (2017, background): “Most of the mutations have long been known to cause a loss of binding of tau to microtubules, resulting in unfolding of the protein to its intrinsically disordered unbound state; several of the mutations also increase the aggregation rate of the resulting unfolded protein (48).”
Neuroinflammation as a Common Feature of Neurodegenerative Disorders (2019, background): “The spectrum of tauopathies covers a large number of disorders such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), frontotemporal dementia (FTD), FTD and parkinsonism linked to chromosome 17, chronic traumatic encephalopathy, and argyrophilic grain disease (Spillantini and”
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans (2019, background): “In diseases called tauopathies that include Alzheimer disease (AD), progressive supranuclear palsy, Pick’s disease, and chronic traumatic encephalopathy, tau becomes hyperphosphorylated and aggregates in structures such as neurofibrillary tangles and neuropil threads (1).”