Pathology of Neurodegenerative Diseases.

By Brittany N. Dugger, Dennis W. Dickson. Cold Spring Harbor Perspectives in Biology, 2017

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Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline (2018, methodology): “Consequently, to establish the feasibility and limitations of this approach, we considered multiple challenges when adapting CNNs to WSIs of archival human brain samples49: (1) WSIs are prohibitively large and can vary in color, necessitating a preprocessing pipeline for their normalization, segment”
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis (2019, background): “Other diseases involving TDP-43 pathological developments are primary lateral sclerosis and progressive muscular atrophy, and together these four diseases are known as TDP-proteinopathies (Figure 1) (Dugger and Dickson, 2017).”