Biphasic Dose Response in Low Level Light Therapy
By Ying-ying Huang, Aaron C.-H. Chen, James Carroll, Michael R Hamblin. Dose-Response, 2009
1,089 citations recorded by the source corpus.
The use of low levels of visible or near infrared light for reducing pain, inflammation and edema, promoting healing of wounds, deeper tissues and nerves, and preventing cell death and tissue damage has been known for over forty years since the invention of lasers. Despite many reports of positive findings from experiments conducted in vitro, in animal models and in randomized controlled clinical trials, LLLT remains controversial in mainstream medicine. The biochemical mechanisms underlying the positive effects are incompletely understood, and the complexity of rationally choosing amongst a large number of illumination parameters such as wavelength, fluence, power density, pulse structure and treatment timing has led to the publication of a number of negative studies as well as many positive ones. A biphasic dose response has been frequently observed where low levels of light have a much better effect on stimulating and repairing tissues than higher levels of light. The so-called Arndt-Schulz curve is frequently used to describe this biphasic dose response. This review will cover the molecular and cellular mechanisms in LLLT, and describe some of our recent results in vitro and in vivo that provide scientific explanations for this biphasic dose response.
Subfields: Insect Science, Pharmacology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/8de8066640b849e67b892689d540311635f8c17a
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Citations in the corpus
- Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation (2018, background): “One feature of PBM that is becoming appreciated is the biphasic dose response (10,11) (also known as the Arndt–Schulz law) (12).”
- Biphasic Dose Response in Low Level Light Therapy – an Update (2011, background): “This review will provide an update to our previous (Huang et al. 2009) coverage of this topic.”
- Mechanisms and applications of the anti-inflammatory effects of photobiomodulation (2017, background): “The “biphasic dose response” describes a situation in which there is an optimum value of the “dose” of PBM most often defined by the energy density (J/cm(2)) [7,8].”