Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

By A. Musarò, Karl J. A. McCullagh, Angelika C. Paul, L. Houghton, G. Dobrowolny, M. Molinaro, E. Barton, H. Sweeney, Nadia A. Rosenthal. Nature Genetics, 2001

1,163 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8dd4fd8c0be9091808d28f376e32f6d729cc1371

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Citations in the corpus

The Molecular Bases of Training Adaptation (2007, background): “Calcineurin appears to act as a co-regulator of muscle hypertrophy with insulin-like growth factor and may also contribute to myogenic proliferation and differentiation of satellite cells during skeletal muscle regeneration (Dunn et al. 1999; Musaro et al. 1999; Dunn et al. 2000; Sakuma et al. 2003;”
Cachexia: pathophysiology and clinical relevance. (2006, background): “Stem cells that express the muscle isoform of IGF-I prevent sarcopenia in old rodents (35, 36).”
Phenotypic Analysis of Meltrin α (ADAM12)-Deficient Mice: Involvement of Meltrin α in Adipogenesis and Myogenesis (2003, background): “On the other hand, insulin-like growth factor I (IGF-I) (32) is one of the cytokines that plays an essential role in adipogenesis and stimulates myogenesis (11, 24, 25).”
Myogenic satellite cells: physiology to molecular biology. (2001, background): “, transgenic overexpression or knockout models), may further define the regulation and signaling pathways of the IGFs and satellite cell biology (8, 25, 132).”
Satellite cells and the muscle stem cell niche. (2013, background): “Elevation of IGF-I signaling within muscle cells in vitro results in muscle hypertrophy with increased DNA and protein content in muscle (6, 34, 87, 103, 365).”
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. (2005, background): “In addition, IGF-1 plays a crucial role in muscle regeneration by promoting the proliferation and differentiation of satellite cells in the muscle, enabling them to fuse to existing muscle fibers and repair damaged regions and subsequently to enhance muscle regenerative capacity [45,46].”
Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models (2011, background): “The effect of an IGF1 isoform (IGF1A) was investigated in a transgenic mouse model, in which expression of this isoform was driven by the myosin light chain 1 fast promoter [51].”
Cellular and molecular regulation of muscle regeneration. (2004, background): “IGF-I and IGF-II appear to ameliorate the aging muscle phenotype and the dystrophic muscle phenotype in mdx mice (25, 222, 286).”
Enhancement of meat production by environmental manipulations in embryo and young broilers (2006, background): “Whereas GH, FGF and HGF have been shown to inhibit myogenic differentiation, IGF-I induces this process, improves muscle hypertrophy (Coleman et al., 1995; Barton-Davis et al., 1999) and protects against age-related muscle atrophy (Musaro et al., 2001).”
Cellular and molecular mechanisms of muscle atrophy (2013, neutral): “Indeed, treatment of muscle cultures with AICAR, an activator of AMPK, increases protein breakdown and atrogin-1 expression via the FoxO family (Nakashima and Yakabe, 2007).”
Sarcopenia: etiology, clinical consequences, intervention, and assessment (2009, background): “The other source of IGF-1 is within the skeletal muscle itself, with two primary variants [34], including one which is produced in response to physical activity and is referred to as mechano growth factor and one which is similar to the mature IGF-1 produced within the liver [35, 36].”
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy (2003, background): “Other work has focused on the phosphatidylinositol-3-OH kinase PI(3)K/Akt (PKB) pathway downstream of IGF-1, demonstrating that Akt is activated during hypertrophy and is sufficient to induce hypertrophy12,13.”