The evolution of vertebrate Toll-like receptors.

By J. Roach, Gwênlyn Glusman, L. Rowen, Amardeep Kaur, M. Purcell, Kelly D. Smith, Leroy Hood, Alan Aderem. Proceedings of the National Academy of Sciences of the United States of America, 2005

1,189 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/8dc1e455f73256ba9a0450402377cfd262b670f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Yong‐jun Liu
2. M. Gilliet
3. Kui Li
4. Sandra N. Lester
5. W. Cao
6. D. Davies
7. Yuanqing Liu
8. D. Segal

In Microbiology

1. Kui Li
2. W. Cao
3. Sandra N. Lester
4. Yong‐jun Liu
5. M. Gilliet

Citations in the corpus

• Genome evolution in fungal plant pathogens: looking beyond the two-speed genome model (2020, neutral): “In plants and animals, for example, genes with roles in immunity often cluster and are located in dynamic regions (Gokcumen et al. , 2011; Kawakatsu et al. , 2016; Laun et al. , 2006; Leister, 2004; Mascher et al. , 2017; Roach et al. , 2005; Seidl and Thomma, 2017).”
• Toll-like receptors in antiviral innate immunity (2013, background): “Based on sequence homology, the vertebrate TLRs are classified into six major families, that is, TLR1, TLR3, TLR4, TLR5, TLR7, and TLR11 [10].”
• Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists (2007, neutral): “Database searches have led to the identification of TLR homologs in many other species, with vertebrates typically having a repertoire of 10 to 12 TLR (refs”
• The Structural Biology of Toll-Like Receptors (2011, background): “The structure of TLRs Based on sequence homologies, vertebrate TLRs can be grouped into six subfamilies, TLR1/2/6/10, TLR3, TLR4, TLR5, TLR7/8/9 and TLR11/12/13/21/22/23 (Matsushima et al., 2007;Roach et al., 2005).”
• Pathogen recognition and innate immunity. (2006, neutral): “Evolutionary Aspects of Innate Immunity Advances in a number of genome projects have revealed that the TLR genes are conserved among many vertebrates, including chicken, Xenopus, zebrafish, and the Japanese pufferfish Takifugu rubripes (Roach et al., 2005).”
• Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “TLR7, TLR8 and TLR9, which have high sequence homolog”
• A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species (2014, background): “CONCLUDING REMARKS Vertebrate TLRs are highly conserved in their coding sequences, functions, and signaling pathways across species (112).”
• Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. (2007, neutral): “To date, 13 mammalian members of the TLR family have been identified, and six subfamilies have been defined based on function and sequence characteristics (Matsushima et al., 2007; Roach et al., 2005).”