Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.

By Akinobu Ota, H. Tagawa, S. Karnan, S. Tsuzuki, A. Karpas, S. Kira, Y. Yoshida, M. Seto. Cancer Research, 2004

816 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/8dbaf1dfccee4e8f6efd32bc25d1a2cafb2b6c29

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In Immunology

In Molecular Biology

In Pathology and Forensic Medicine

Citations in the corpus

MicroRNA control in the immune system: basic principles. (2009, background): “…13q31, a genomic region that is frequently amplified in lymphomas and solid tissue cancers, and the mature miRNAs encoded by this locus are expressed in high amounts in those cancer cells (Hayashita et al., 2005; Lu et al., 2005; Ota et al., 2004; Tagawa and Seto, 2005; Zhang et al., 2007).”
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. (2008, neutral): “A role for miR-17� 92 in the pathogenesis of human cancers is suggested by its frequent amplification and overexpression in diffuse large B cell lymphomas ( Ota et al., 2004 ) and in other tumor types, including small cell lung cancer (Hayashita et al., 2005; Matsubara et al., 2007).”
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes (2008, background): “The miR-17-92 miRNA cluster is located at human chromosome 13q31 in a genomic region that is often amplified in lymphomas and other cancers, and cancer cells have high expression of the mature miRNA molecules encoded by this locu”
microRNAs in cancer (2013, background): “The miR-17/92 cluster is located within ∼1 kb of an intron of the C13orf25 locus on human chromosome 13q31, a region frequently amplified in several types of lymphoma and solid tumors (132, 133).”
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease (2013, neutral): “In 2004, a novel gene, ‘chromosome 13 open reading frame 25’ or C13orf25 for short, was identified.(9) Analysis of 70 human B-cell lymphoma cases showed amplification of this region.”
miRiad roles for the miR-17-92 cluster in development and disease. (2008, background): “~7 kb primary transcript known as C13orf25 (Ota et al., 2004).”
MicroRNAs and cancer: short RNAs go a long way. (2009, background): “…six miRNAs that are processed from a single primary transcript, was initially linked to cancer based on the observation that it maps to a chromosomal region that is frequently amplified in a subset of human B cell lymphomas (Ota et al., 2004) and overexpressed in a variety of other human cancers.”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “17-92 miRNAs observed within a variety of lymphomas, lung cancer, colon, pancreas and prostate cancers [241, 294, 297-299].”
MicroRNAs in body fluids—the mix of hormones and biomarkers (2011, neutral): “3, a chromosomal region amplified in many types of cancer”