Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae

By H. Yigit, A. Queenan, Gregory J. Anderson, A. Doménech-Sánchez, J. Biddle, Christine D. Steward, S. Albertí, K. Bush, F. Tenover. Antimicrobial Agents and Chemotherapy, 2008

712 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/8da99e5f9fee9e4a32a0722f2c40fadf051c22d5

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In Molecular Biology

1. L. Poirel
2. P. Nordmann
3. T. Naas
4. J. Pitout
5. G. Meletis
6. L. Logan
7. Robert A. Weinstein
8. J. Munita

In Molecular Medicine

1. L. Poirel
2. P. Nordmann
3. J. Pitout
4. Robert A. Weinstein
5. L. Logan
6. Amy Mathers
7. G. Peirano
8. G. Meletis

Citations in the corpus

• Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. (2011, background): “Endimiani A, Carias LL, Hujer AM et al. (2008) Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States.”
• The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace (2017, background): “pneumoniae was discovered in a patient in a North Carolina hospital in 1996 [69].”
• Carbapenem resistance: overview of the problem and future perspectives (2016, background): “In the USA alone, 2 million people acquire serious infections due to antibiotic-resistant bacteria each year and according to the Centers for Disease Control and Prevention (CDC), 23,000 of them die as a result [CDC, 2013].”
• The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae (2015, background): “K. pneumoniae with blaKPC was first identified in a non-ST258 isolate during 1996 in the Southern United States (122).”
• Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance (2017, background): “The first qnr gene was discovered on a plasmid of K. pneumoniae isolated in 1994 in the United States (Martı́nez-Martı́nez, Pascual and Jacoby 1998).”
• Mechanisms of Antibiotic Resistance (2016, result): “KPC was fi rst reported in 1996 from a K. pneumoniae strain recovered from a patient in North Carolina (25).”
• Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. (2012, background): “aeruginosa, only anecdotal reports of currently important carbapenemases such as KPCs belonging to class A [6] or OXA-48 belonging to class D [7] had been published, and NDM-1 belonging to class B had not been described [8].”
• Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. (2011, background): “KPC-producing Enterobacteriaceae were first reported in a clinical specimen from a patient in North Carolina in 2001 [7].”
• Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance (2015, background): “pneumoniae with blaKPC was first identified in a non-ST258 isolate during 1996 in the Southern United States (42).”
• Klebsiella pneumoniae: Going on the Offense with a Strong Defense (2016, background): “The worldwide dissemination of ST258 has resulted in the distribution of its associated KPC across a number of different countries and continents (10, 16).”
• Hospital Epidemiology and Infection Control in Acute-Care Settings (2011, background): “The first carbapenemase-producing Klebsiella species were reported in the late 1990s (360); however, these organisms did not gain notoriety until outbreaks of KPC-producing Klebsiella species were reported around the world (34, 36, 180, 306, 332).”