Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance

By J. Pitout, P. Nordmann, L. Poirel. Antimicrobial Agents and Chemotherapy, 2015

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Klebsiella pneumoniae: Going on the Offense with a Strong Defense (2016, background): “It requires the carriage of these carbapenem resistance genes but often also requires the carriage of other -lactamases and/or mutations in outer membrane proteins (OMPs) that render the bacteria more resistant to -lactams, particularly in combination with the expression of a carbapenemase (10, 31).”
Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods (2016, background): “ST258 may be a hybrid clone that was created by a large recombination event between ST11 and ST442 (Pitout et al., 2015).”