Rafts defined: a report on the Keystone symposium on lipid rafts and cell function Published, JLR Papers in Press, April 27, 2006.

By L. Pike. Journal of Lipid Research, 2006

1,490 citations recorded by the source corpus.

The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23–28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts. What emerged from the meeting was a consensus definition of a membrane raft: “Membrane rafts are small (10–200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.” This definition helps to clarify current thinking in a field that has been plagued by the heterogeneous and sometimes ephemeral nature of its subject.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d815f301d556122a8404cb9e2604a7989e84f8cf

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Citations in the corpus

SINGLE-PARTICLE TRACKING (2009, background): “Their existence, size, and properties are controversial [97].”
Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. (2007, background): “The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23–28, 2006 in Steamboat Springs, CO) advanced the following consensus definition: “Membrane rafts are small (10–200 nm), heterogeneous, highly dynamic, steroland sphingolipid-enriched domains that compartmentalize cellular proces”
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “Such small microdomains (10–200 nm) that are sphingolipid- and cholesterol-enriched are called “lipid rafts” or “membrane rafts” (Zegers and Hoekstra, 1998; Pike, 2006).”
The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. (2014, background): “It is thought that small, unstable lipid rafts containing cholesterol and sphingolipids undergo dynamic changes which result in larger signaling rafts that are characterized by clustering and stabilization of raft molecules [214,221,222].”
Lipid rafts: at a crossroad between cell biology and physics (2007, background): “A provisional contemporary definition of rafts that begins to embody these complexities emerged at the 2006 Keystone Symposiu”
Local PIP2 signals: when, where, and how? (2007, background): “One of the early supports for the existence of membrane rafts was the fact that, biochemically, it is possible to isolate light membrane fractions that contain larger amounts of PIP2 than the average cell membrane [68, 69].”
Lipid rafts in the bovine milk fat globule membrane revealed by the lateral segregation of phospholipids and heterogeneous distribution of glycoproteins (2010, background): “A currently accepted defini tion of rafts is: small (10–20 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartimentalise cellular processes (Pike, 2006).”