The Role of Presenilins in γ-Secretase Activity*

By M. Wolfe, Christian Haass. Journal of Biological Chemistry, 2001

104 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/8d7bace3edb560acf3bb661f3b44dfc4c47cfddc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. Christian Haass

In Pharmacology

1. M. Condron
2. Christian Haass
3. David B. Teplow

In Physiology

1. David B. Teplow
2. M. Condron
3. Christian Haass

Citations in the corpus

• Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch (2001, background): “…PSs themselves could be unusual aspartyl proteases, which mediate the γ-secretase cut (Wolfe et al., 1999; for review see Steiner and Haass, 2000; Wolfe and Haass, 2001). γ-secretase cleavage results in the production of Aβ and the generation of the small hydrophobic p7 (Haass and Selkoe, 1993)…”