A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

By M. Whorton, M. Bokoch, S. Rasmussen, Bo Huang, Richard N. Zare, Brian K. Kobilka, R. Sunahara. Proceedings of the National Academy of Sciences of the United States of America, 2007

691 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8d3de3484879b4cc3f3e1a228f87569273c0886e

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update (2011, background): “Monomeric receptors are sufficient to induce signaling (Chabre and le Maire 2005 Whorton et al., 2007, 2008, White et al., 2007).”
Heterotrimeric G protein activation by G-protein-coupled receptors (2008, background): “, and monomeric β 2 -adrenergic receptors that are encapsulated in lipid bilayer nanodiscs can efficiently activate G s”
Structure-based drug screening for G-protein-coupled receptors. (2012, background): “For example, the affinity of the β2AR for the agonist isoproterenol is 100 fold greater when coupled to the G protein Gs[40, 41].”
Crystal Structure of the β2Adrenergic Receptor-Gs protein complex (2011, positive): “Nb35 and Nb37 were enriched by two rounds of biopanning on the β 2 AR-Gs-BI-167107 ternary complex embedded in biotinylated high-density lipoprotein particles 34 .”