A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

By S. Feske, Y. Gwack, M. Prakriya, Sonal Srikanth, Sven-Holger Puppel, Bogdan Tanasa, P. Hogan, R. Lewis, Mark J. Daly, Anjana Rao. Nature, 2006

2,312 citations recorded by the source corpus.

Subfields: Sensory Systems

View Paper: https://www.semanticscholar.org/paper/8d1b4d9d2d784a642ad0b25996a316a3f2532968

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Sensory Systems

1. R. Lewis
2. M. Prakriya
3. S. Feske
4. Jie Zheng
5. M. Trudeau
6. Anjana Rao
7. P. Hogan
8. Heike Wulff

Citations in the corpus

• Store-Operated Calcium Channels. (2015, positive): “Genetic studies in humans and knockout studies in mice complement these expression profiles and confirm an important role for Orai1 in a variety of immune cells (T cells, mast cells, B cells, NK cells) as well as nonimmune cells (fibroblasts, skeletal muscle, platelets, microglia, endothelial cells,”
• SOAR and the polybasic STIM1 domains gate and regulate the Orai channels (2009, neutral): “(1) Orail1+ SOAR (2) Orail1 + SOARLQ/AA (3) Orai1 + STIM1 (4) Orail1 + STIM1LQ/AA”
• Voltage-gated Potassium Channels as Therapeutic Drug Targets (2009, neutral): “In proliferating cells, such as lymphocytes or cancer cells, K V channels provide the counterbalancing K + efflux for the Ca 2+ influx through store-operated inward-rectifier Ca 2+ channels — such as the Ca 2+ release-activated Ca 2+ channel (CRAC”
• Physiology of Astroglia. (2018, neutral): “The NAADP receptors were also visualized in cortical astrocytes in vitro with fluorescent probe NED-19, which revealed punctate staining with a high degree of colocaliza(5)Named after three Greek sister-goddesses Orai, the keepers of the Heaven’s gate (505).”
• Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai (2006, background): “More importantly, we conclude that Orai is a bona fide ion channel, based on the following: (1) RNA-interference-mediated knockdown of Orai expression suppresses thapsigargin-dependent Ca2þ influx and CRAC channel activity; (2) overexpression of Orai with or without Stim augments CRAC currents that ”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “This was followed within a year by the discovery of the Orai1 protein as the channel component of ICRAC, the highly Ca(2) -selective current representing the major form of SOCE (435, 1635, 1802).”
• Handbook of ion channels (2015, background): “Simultaneously, genome-wide RNAi screens for genes involved in SOCE in Drosophila S2 cells carried out by three groups identified a novel gene as a critical mediator of Drosophila SOCE [43,53,54].”
• Ion Channels in Innate and Adaptive Immunity (2015, background): “Patients homozygous for mutations in ORAI1 or STIM1 that lack SOCE completely, but not their heterozygous relatives with partial impairment of SOCE, show increased susceptibility to viral and bacterial infections (26, 123).”