Oxidative stress in Parkinson's disease

By P. Jenner. Annals of Neurology, 2003

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress (2008, neutral): “A growing number of clinical and experimental reports implicate mitochondrial dysfunctions and oxidative stress in the pathogenesis of PD (1, 2).”
Metals, oxidative stress and neurodegenerative disorders (2010, positive): “The link between oxidative stress and PD is supported by postmortem analysis showing the oxidative stressinduced nigral cell degeneration [ 99 ].”
Inflammation and neurodegeneration in Parkinson's disease. (2004, background): “Such activated microglia may produce large amounts of superoxide radicals, which may well be the major source of the oxidative stress believed to be largely responsible for dopaminergic cell death in PD [20,21].”
Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases (2019, background): “Dopaminergic neurons of the substantia nigra, where the basal level of free radicals is important [137], are particularly sensitive to d generation.”