Inflammation and neurodegeneration in Parkinson's disease.

By P. Mcgeer, E. Mcgeer. Parkinsonism & Related Disorders, 2004

638 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/b9af8ed64bf060aadb713f26b0612e26cfa9ac11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. P. Whitton
2. C. Glabe
3. Elias K. Michaelis
4. P. Jenner
5. S. Duty

In Neurology

1. P. Whitton
2. C. Glabe
3. Elias K. Michaelis
4. S. Duty
5. P. Jenner

Citations in the corpus

• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “For instance, investigators have observed activated macrophages in the brain of patients with various neurodegenerative diseases (163, 164), as well as in plaques obtained from patients with atherosclerosis (288).”
• Epidemiology and etiology of Parkinson’s disease: a review of the evidence (2011, background): “studies showing the presence of activated microglia cells and increased levels of inflammatory cytokines in substantia nigra and striatum [548–551].”
• The Role of the Anaphylatoxins in Health and Disease (2009, positive): “Similar scenarios may apply to Parkinson disease (McGeer and McGeer, 2004), Huntington's disease (Singhrao et al., 1999) and age relate macular degeneration (AMD) (Hageman et al., 2005).”
• Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Neurodegenerative Disease Inflammation has been well established as a major component of neurodegenerative disorders, but it has never been clear if this was a direct cause of the disease or a consequence of the progressive degenerative process that was occurring (363, 364).”
• Inflammation as a causative factor in the aetiology of Parkinson's disease (2007, background): “Additionally, the presence of MAC has been identified in PD (McGeer and McGeer, 2005), and elevated levels of C-reactive protein, an inflammation marker, has been shown in the SN of PD patients (McGeer and McGeer, 2004).”
• Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. (2006, background): “Chronic inflammation may also be a component of the core degenerative pathway as it is frequently observed in neurodegenerative diseases [19,20, 45 ].”