Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.

By Yanfang Liu, Yan Gu, Yanmei Han, Qian Zhang, Zhengping Jiang, Xiang Zhang, Bo Huang, Xiaoqing Xu, Jianming Zheng, Xuetao Cao. Cancer Cell, 2016

595 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8c10040a4c88eb0a694306453816afb7c972c235

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Lin Zhang
2. Yang Liu
3. D. Quail
4. J. Joyce
5. Dihua Yu
6. Joana Maia
7. Xuetao Cao
8. A. Becker

Citations in the corpus

• The biology, function, and biomedical applications of exosomes (2020, unknown): “Exogenous bolus doses of supraphysiological levels of exosomes into mice were associated with a penetrant cellular phenotype, includingmodulation of cancer progression (144, 151, 165, 235), induction of neoplasia (148), and regeneration of tissue (236).”
• Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “TLR3 activation in lung epithelial cells by tumor-exosomal non-coding snRNA enhances expression of S100A8, A100A9, MMP9, Bv8 and fibronectin which, in turn, contributes to lung PMN formation (Liu et al., 2016).”
• Exosomes in cancer development, metastasis, and immunity (2019, background): “Additionally, it was reported that snRNAs in exosomes derived from lung cancer or melanoma promoted lung pre-metastatic niches by activating TLR3 and releasing cytokines which recruited neutrophils into the lung [105].”
• The microenvironmental landscape of brain tumors (2017, background): “It is also becoming apparent that BBB integrity is heterogeneously affected within brain tumors (Lockman et al., 2010; Morikawa et al., 2015).”
• Characteristics and Significance of the Pre-metastatic Niche. (2016, background): “In breast cancer, aberrant expression of VCAM-1 in the bone microenvironment promotes the transition from indolent micrometastases to overt bone metastasis by engaging a4b1-positive osteoclast progenitors (Lu et al., 2011).”
• Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “…as crucial mediators in the pre-metastatic niche development (Wculek and Malanchi, 2015), as breast cancer-derived exosomal RNAs can activate host stromal TLR3, inducing neutrophil recruitment, which is critical for the setup of pre-metastatic niches (Kenific et al., 2016; Liu et al., 2016).”