Caspases in cell death, inflammation and disease

By N. Van Opdenbosch, M. Lamkanfi. Immunity, 2019

1,063 citations recorded by the source corpus.

Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of additional inflammasome platforms and pathways that regulate activation of inflammatory caspases; the discovery of gasdermin D as the effector of pyroptosis and interleukin (IL)-1 and IL-18 secretion; and the existence of substantial crosstalk between inflammatory and apoptotic initiator caspases. A better understanding of the mechanisms regulating caspase activation has supported initial efforts to modulate dysfunctional cell death and inflammation pathways in a suite of communicable, inflammatory, malignant, metabolic and neurodegenerative diseases. Here, we review current understanding of caspase biology with a prime focus on the inflammatory caspases, and outline important topics for future experimentation.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/6eb94d48bd36b5eed340e603ff71e80bf1b37829

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Citations in the corpus

• Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis (2020, background): “Genetic and biochemical inactivation of caspases has revealed caspase-independent forms of cell death and a more complex relationship between apoptosis and inflammation (33, 58, 59).”