Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

By Muyang Li, C. Brooks, F. Wu-Baer, Delin Chen, R. Baer, W. Gu. Science, 2003

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p53 ubiquitination: Mdm2 and beyond. (2006, background): “Mdm2 was recently found to differentially catalyze monoubiquitination and polyubiquitination of p53 in a dosage-dependent manner (Li et al., 2003).”
Post-translational modification of p53 in tumorigenesis (2004, background): “Although the significance is not yet clear, recent data indicate that MONOUBIQUITYLATION might act as a signal in nuclear export for p53, and that different levels of MDM2 can induce both mono- and POLYUBIQUITYLATION in a dose-dependent manner, so determining the fate of p53 (Ref”
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 (2010, neutral): “Localizes in the Cytoplasm and Counteracts Mdm2 Action Previous studies suggest that ubiquitination of p53 by Mdm2 could induce p53 translocation from nucleus to cytoplasm (Boyd et al., 2000; Geyer et al., 2000; Li et al., 2003; Stommel et al., 1999).”