LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

By Y. Gong, R. Slee, N. Fukai, G. Rawadi, S. Roman-Roman, Anthony M. Reginato, Hongwei Wang, T. Cundy, Francis H Glorieux, D. Lev and 52 more. Cell, 2001

2,274 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8bd86e3d41f591fa042f290cfe701ffe09e089ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. Fanxin Long
5. W. Birchmeier
6. S. Angers
7. Z. Steinhart
8. L. Bonewald

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. Fanxin Long
5. Xi He
6. S. Angers
7. W. Birchmeier
8. K. Tamai

Citations in the corpus

• The Regulation of Differentiation in Mesenchymal Stem Cells (2010, positive): “At the clonal level, however, not all clonal populations are able to differentiate into all three lineages, as some MSC clones may lack differentiation into at least one lineage (Pittenger et al. , 1999).”
• TSH is a negative regulator of skeletal remodeling. (2003, positive): “Likewise, the two subunits explants were maintained in culture with 1% agarose under differentiating conditions (Gong et al., 2001).”
• Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor (2002, background): “However, the recent findings that LRP5 is inactivated in osteoporosis-pseudoglioma syndrome patients (Gong et al., 2001) and is mutated in patients with the high bone mass syndrome (Little et al.”
• Sequential roles of Hedgehog and Wnt signaling in osteoblast development (2004, background): “Interestingly, several studies have suggested that activation of canonical Wnt signaling can induce osteoblast differentiation in cell culture models (Bain et al., 2003; Gong et al., 2001; Rawadi et al., 2003).”