TSH is a negative regulator of skeletal remodeling.

By E. Abe, R. Marians, Wanqin Yu, Xue‐Bin Wu, T. Ando, Yanan Li, J. Iqbal, Leslie S. Eldeiry, G. Rajendren, H. Blair and 2 more. Cell, 2003

673 citations recorded by the source corpus.

How researchers see this paper

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Skeletal remodeling in health and disease (2007, background): “However, recent studies show that TSH reduces the formation, function and survival of osteoclasts by acting on a G-protein-coupled receptor on osteoclast”
Growth hormone, insulin-like growth factors, and the skeleton. (2008, background): “TSH deficiency may also contribute to the bone loss (271, 272).”
The clinical significance of subclinical thyroid dysfunction. (2008, background): “TSH may also affect skeletal remodeling by interacting with the specific receptors expressed on bone cells (461).”
FSH directly regulates bone mass. (2006, neutral): “(J) Effect of FSH on TRAP-positive osteoclast numbers in wild-type (WT), FSHR À/À , and TSHR À/À cells.”