c-Myc and Cancer Metabolism
By Donald M Miller, S. Thomas, A. Islam, David E. Muench, Kara C. Sedoris. Clinical Cancer Research, 2012
764 citations recorded by the source corpus.
The processes of cellular growth regulation and cellular metabolism are closely interrelated. The c-Myc oncogene is a “master regulator” which controls many aspects of both of these processes. The metabolic changes which occur in transformed cells, many of which are driven by c-Myc overexpression, are necessary to support the increased need for nucleic acids, proteins, and lipids necessary for rapid cellular proliferation. At the same time, c-Myc overexpression results in coordinated changes in level of expression of gene families which result in increased cellular proliferation. This interesting duality of c-Myc effects places it in the mainstream of transformational changes and gives it a very important role in regulating the “transformed phenotype.” The effects induced by c-Myc can occur either as a “primary oncogene” which is activated by amplification or translocation or as a downstream effect of other activated oncogenes. In either case, it appears that c-Myc plays a central role in sustaining the changes which occur with transformation. Although efforts to use c-Myc as a therapeutic target have been quite frustrating, it appears that this may change in the next few years. Clin Cancer Res; 18(20); 5546–53. ©2012 AACR.
Subfields: Cancer Research, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/a0da2d69fd02147e080cbcd5354c1c50dfe7650f
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Citations in the corpus
- Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials (2020, background): “Aberrant expression of cMyc has been confirmed in most malignant tumors.(125) As a result, c-Myc has become a research hot spot.”
- Signal transduction in cancer. (2015, neutral): “Myc regulates glucose uptake, glycolysis, and the pentose phosphate pathway (Ying et al. 2012) and induces synthesis of glutamine transporters and the enzyme glutaminase (GLS), which converts glutamine into glutamate that can bemetabolized inmitochondria (Miller et al. 2012; Dang 2013).”