Mh1 domain of Smad is a degraded homing endonuclease.

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ECOD: An Evolutionary Classification of Protein Domains (2014, background): “Fortunately, many examples have shown that analysis of proteins in the context of their distant homologs provides functional clues that advance biological research [15,16,17,18].”
COMPASS: a tool for comparison of multiple protein alignments with assessment of statistical significance. (2003, background): “The significant structural similarity of MH1 to the zinc binding I-PpoI endonuclease, as well as the deviations from ideal chain geometry of MH1 strongly suggest the presence of the metalbinding site formed by three cysteine residues (C64, C109 and C121) and one histidine H126 (Figure 8(c)), which r”