The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.

By Zhigao Wang, Hui Jiang, She Chen, Fenghe Du, Xiaodong Wang. Cell, 2012

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Crosstalk between apoptosis, necrosis and autophagy. (2013, background): “Inte-restingly, PGAM5, a mitochondrial phosphoglyceratemutase, was also recently reported to associate with the necrosome, providing a potential point of convergence for increased mitochondrial ﬁ ssion and necroptosis ([40,41]; reviewed in [37]).”
Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL* (2013, background): “Following preparation of cell extracts, immunoprecipitation, and electrophoretic separation on denaturing polyacrylamide gels followed by transfer (4, 9), immunoblot analysis was performed on the following antibodies: mouse anti-(cid:2) -actin (clone AC-74; Sigma); rabbit anti-Casp8 (Cell Signaling)”
Necroptosis: Mechanisms and Relevance to Disease (2016, neutral): “Initial beliefs that necroptosis would proceed upon mitochondrial fragmentation mediated by PGAM family member 5, serine/ threonine protein phosphatase, mitochondrial (PGAM5) and dynamin 1-like (DNM1L) (25) have been conclusively rejected (26–29).”
Apoptosis, autophagy, necroptosis, and cancer metastasis (2015, background): “At the second checkpoint, activated caspase-8 cleaves and abolishes the activities of RIP1, RIP3, and CYLD [118-120].”